Julho verde alerta para o Câncer de Ovário

O câncer de ovário é a segunda neoplasia ginecológica mais comum, atrás apenas do câncer do colo do útero. A quase totalidade das neoplasias ovarianas (95%) é derivada das células epiteliais (que revestem o ovário). O restante provém de células germinativas (que formam os óvulos) e células estromais (que produzem a maior parte dos hormônios femininos).

O que aumenta o risco?

Idade – A incidência de carcinoma epitelial de ovário aumenta com o avanço da idade.

Fatores reprodutivos e hormonais – O risco de câncer de ovário é aumentado em mulheres com infertilidade e reduzido naquelas que tomam contraceptivos orais (pílula anticoncepcional) ou que tiveram vários filhos. Por outro lado, mulheres que nunca tiveram filhos parecem ter risco aumentado para câncer de ovário.

A menarca (primeira menstruação) precoce (antes dos 12 anos) e a idade tardia na menopausa (após os 52 anos) podem estar associadas a risco aumentado de câncer de ovário. 

A infertilidade é fator de risco para o câncer de ovário, mas a indução da ovulação para o tratamento da infertilidade não parece aumentar o risco de desenvolver a doença. 

O risco de câncer de ovário com terapia hormonal pós-menopausa aparenta ser pequeno. 

História familiar – Histórico familiar de cânceres de ovário, colorretal e de mama está associado a risco aumentado de câncer de ovário.

Fatores genéticos – Mutações em genes, como BRCA1 e BRCA2, estão relacionadas a risco elevado de câncer de mama e de ovário. 

Obesidade – Parece aumentar o risco de desenvolvimento de câncer de ovário.

PREVENÇÃO

As mulheres devem estar atentas aos fatores de risco e consultar regularmente o seu médico, principalmente a partir dos 50 anos.   

O exame preventivo ginecológico (Papanicolaou) não detecta o câncer de ovário, já que é específico para detectar o câncer do colo do útero.

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