O que causa o câncer?

O câncer não tem uma causa única. Há diversas causas externas (presentes no meio ambiente) e internas (como hormônios, condições imunológicas e mutações genéticas). Os fatores podem interagir de diversas formas, dando início ao surgimento do câncer.

Entre 80% e 90% dos casos de câncer estão associados a causas externas. As mudanças provocadas no meio ambiente pelo próprio homem, os hábitos e o estilo de vida podem aumentar o risco de diferentes tipos de câncer.

Entende-se por ambiente o meio em geral (água, terra e ar), o ambiente de trabalho (indústrias químicas e afins), o ambiente de consumo (alimentos, medicamentos) e o ambiente social e cultural (estilo e hábitos de vida). Os fatores de risco ambientais de câncer são denominados cancerígenos ou carcinógenos. Esses fatores alteram a estrutura genética (DNA) das células.

As causas internas estão ligadas à capacidade do organismo de se defender das agressões externas. Apesar de o fator genético exercer um importante papel na formação dos tumores (oncogênese), são raros os casos de câncer que se devem exclusivamente a fatores hereditários, familiares e étnicos.

Existem ainda alguns fatores genéticos que tornam determinadas pessoas mais suscetíveis à ação dos agentes cancerígenos ambientais. Isso parece explicar porque algumas delas desenvolvem câncer e outras não, quando expostas a um mesmo carcinógeno.

O envelhecimento natural do ser humano traz mudanças nas células, que as tornam mais vulneráveis ao processo cancerígeno. Isso, somado ao fato de as células das pessoas idosas terem sido expostas por mais tempo aos diferentes fatores de risco para câncer, explica, em parte, o porquê de o câncer ser mais frequente nessa fase da vida.

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