O câncer de ovário é a segunda neoplasia ginecológica mais comum, atrás apenas do câncer do colo do útero. A quase totalidade das neoplasias ovarianas (95%) é derivada das células epiteliais (que revestem o ovário). O restante provém de células germinativas (que formam os óvulos) e células estromais (que produzem a maior parte dos hormônios femininos).
O que aumenta o risco?
Idade – A incidência de carcinoma epitelial de ovário aumenta com o avanço da idade.
Fatores reprodutivos e hormonais – O risco de câncer de ovário é aumentado em mulheres com infertilidade e reduzido naquelas que tomam contraceptivos orais (pílula anticoncepcional) ou que tiveram vários filhos. Por outro lado, mulheres que nunca tiveram filhos parecem ter risco aumentado para câncer de ovário.
A menarca (primeira menstruação) precoce (antes dos 12 anos) e a idade tardia na menopausa (após os 52 anos) podem estar associadas a risco aumentado de câncer de ovário.
A infertilidade é fator de risco para o câncer de ovário, mas a indução da ovulação para o tratamento da infertilidade não parece aumentar o risco de desenvolver a doença.
O risco de câncer de ovário com terapia hormonal pós-menopausa aparenta ser pequeno.
História familiar – Histórico familiar de cânceres de ovário, colorretal e de mama está associado a risco aumentado de câncer de ovário.
Fatores genéticos – Mutações em genes, como BRCA1 e BRCA2, estão relacionadas a risco elevado de câncer de mama e de ovário.
Obesidade – Parece aumentar o risco de desenvolvimento de câncer de ovário.
PREVENÇÃO
As mulheres devem estar atentas aos fatores de risco e consultar regularmente o seu médico, principalmente a partir dos 50 anos.
O exame preventivo ginecológico (Papanicolaou) não detecta o câncer de ovário, já que é específico para detectar o câncer do colo do útero.
Pingback: Primeiros sintomas de câncer no ovário - Dr. Valdemir Ferreira
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