Pancreatite (CID 10 – K85) é a inflamação no pâncreas. O pâncreas é uma glândula localizada atrás do estômago no abdome superior. Entre as suas funções está fazer a digestão das gorduras e carboidratos que ingerimos usando o suco pancreático, substância que contém enzimas digestivas.
Além disso, o pâncreas é responsável por produzir os hormônios insulina e glucagon. A insulina é responsável por reduzir as taxas de açúcar no sangue, ao passo que o glucagon tem o efeito contrário, aumentando essas concentrações. Assim o pâncreas funciona como dois órgãos existindo em um só.
Tipos
A pancreatite pode ocorrer de forma aguda ou crônica.
Pancreatite é grave?
Os casos leves de pancreatite podem desaparecer sem tratamento, mas casos graves podem causar complicações com risco de vida.
Pancreatite aguda
O início da pancreatite aguda é frequentemente muito repentina. A inflamação geralmente desaparece dentro de poucos dias, uma vez que o tratamento começa. De acordo com o DATASUS, no Brasil são registrados cerca de 15,9 casos a cada 100 mil habitantes todos os anos.
Os cálculos biliares são a causa mais comum da pancreatite aguda. O cálculo biliar é uma massa pequena e sólida que forma a partir de bile na vesícula. O pâncreas e a vesícula biliar se ligam pelo ducto biliar, através do qual a bile e outras enzimas digestivas passam para o intestino durante a digestão. Os cálculos, quando escapam da vesícula biliar e passam pelo ducto biliar podem causar inflamação no pâncreas. A outra causa comum de pancreatite aguda é a ingestão de álcool, às vezes de forma intensa. Diversas outras situações podem causar pancreatite como traumas, uso de remédios e aumento do triglicérides no sangue.
Pancreatite crônica
A pancreatite crônica é uma inflamação que não acaba e se perpetua. Os pacientes com pancreatite crônica podem sofrer danos permanentes ao pâncreas. Sua incidência é estimada entre cinco e 10 casos para cada 100 mil indivíduos por ano.
O tecido cicatricial se desenvolve a partir de inflamação de longa duração e pode fazer o pâncreas parar de produzir a quantidade normal de enzimas digestivas. Como resultado, é provável que você tenha problemas para digerir gorduras. Em casos avançados a parte endócrina pode ser acometida e os pacientes evoluem com Diabetes Mellitus.
O abuso de álcool é a causa mais comum de pancreatite crônica em adultos. Doenças autoimunes e doenças genéticas, tais como a fibrose cística, também podem causar a pancreatite crônica em alguns pacientes.
Causas
Pancreatite ocorre quando as enzimas digestivas produzidas no pâncreas tornam-se ativadas enquanto no interior do pâncreas, causando danos ao órgão.
Durante a digestão normal, as enzimas pancreáticas inativadas se movem através de dutos em seu pâncreas e viajam para o intestino delgado, onde as enzimas são ativadas e ajudam na digestão. Na pancreatite, as enzimas são ativadas quando ainda no pâncreas. Isto faz com que as enzimas destruam as estruturas das células, causando inflamação e os sinais e sintomas associados com a pancreatite.
Com acessos repetidos de pancreatite aguda, o dano ao pâncreas pode ocorrer e levar a pancreatite crônica. O tecido cicatricial pode se formar no pâncreas, causando a perda da função. Um pâncreas que não funcionam bem pode causar problemas de digestão e diabetes.
Segundo o gastroenterologista Henrique Perobelli Schleinstein, as causas mais comuns de pancreatite são cálculos na via biliar, alcoolismo e hipertrigliceridemia (triglicérides altos). Além disso, causas autoimunes também estão envolvidas mais raramente, assim como deformidades embriológicas como o pâncreas divisum.
Fatores de risco
Alguns fatores são considerados de risco para a pancreatite aguda e pancreatite crônica, incluindo:
Alcoolismo
Cálculos biliares
Cirurgia abdominal
Certos medicamentos
Tabagismo
Fibrose cística
Colangiopancreatografia retrógrada endoscópica, quando usado no tratamento de cálculos biliares
História familiar de pancreatite
Níveis elevados de cálcio no sangue (hipercalcemia), que podem ser causadas por uma glândula paratireoide hiperativa (hiperparatiroidismo)
Altos níveis de triglicérides no sangue (hipertrigliceridemia)
Infecção
Lesão no abdômen
Câncer de pâncreas.
Pancreatite pode ser hereditária?
O médico gastroenterologista Henrique Perobelli Schleinstein, indica que a pancreatite pode sim ser hereditária. existem casos de pancreatite crônica hereditária, uma doença autossômica dominante que acontece pela falha na produção de tripsinogênio, uma enzima pancreática e pode afetar jovens.
Sintomas de Pancreatite
Sintomas de pancreatite aguda incluem:
Dor abdominal superior
Dor abdominal que se irradia para as costas
Dor abdominal que se sente pior depois de comer
Náusea
Vômitos
Febre.
Sintomas de pancreatite crônica incluem:
Dor abdominal superior intensa
Perder peso sem esforço
Fezes gordurosas e fedorentas (esteatorreia).
Outros sintomas de pancreatite incluem:
Febre
Ritmo cardíaco acelerado
Suor
Pele ou a parte branca dos olhos com cor amarelada (icterícia)
Choque.
Outras condições que têm sintomas semelhantes: obstrução intestinal, apendicite, colecistite, úlcera péptica, e diverticulite.
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